Integrating Functional Genomics and Clinical Trials Workshop
Royal Society of Medicine, London, 31st January – 1st February 2005

Functional genomics studies are providing new information about cancer at a massive rate. While there is outstanding potential for application in cancer prevention and care it is becoming increasingly clear that interpretation of data is a complex problem which needs to be approached in a systematic way if valid conclusions are to be drawn. Clinical trials in which there are defined populations, and careful quality control, provide an ideal situation in which to investigate the limitations and power of functional genomics data. There are many potential sources of error in bringing the diverse molecular and clinical data together and standards are required for data acquisition, and the management of data at the molecular level (Bioinformatics) and the clinical level (clinical informatics). The workshop brought together a diverse group of people including functional genomics and clinical investigators, bioinformatics and clinical informatics experts and computer scientists in order to define the issues and determine a strategy for progress towards optimal exploitation of functional genomics in cancer research.

The presentations from the workshop are available below:

	Agenda (PDF)
	Introduction and aims of workshop (Richard Begent) (PDF)
	Review of clinical significance of functional genomics (James Brenton) (PDF)
	Review of clinical informatics standards and systems (Dipak Kalra) (PDF)
	caBIG™, CaArray and CaIntegrator (Sue Dubman) (PDF)
	Standards and infrastructure for sharing microarray data (Alvis Brazma) (PDF)
	Attack of the Clones: HL7 Clones vs. Genomic Clones... (Amnon Shabo) (PDF)
	NCRI planning matrix/platform reference model/data sharing (Peter Kerr & Anthony Finkelstein) (PDF)
	CancerGrid (Jim Davies, Steve Harris & Sylvia Nagl) (PDF)
	NCI: Rembrandt and ISPY Studies (Subha Madhaven) (PDF)
	Ovarian cancer, genomics and CSC/IC Microarray Centre (Hani Gabra & Tim Aitman) (PDF)
	Breast cancer genetics and clinical trials (James Mackay) (PDF)
	Ontologies, terminologies and pitfalls (Alan Rector) (PDF)
	TransBIG project & data analysis (Thierry Sengstag) (PDF)
	EPR & NCRN data systems for clinical trials (Monica Jones) (PDF)

Click here to download a report summarising the outcomes of the workshop.